Bladder symptoms assessed with overactive bladder questionnaire in Parkinson's disease
Identifieur interne : 002A55 ( Main/Corpus ); précédent : 002A54; suivant : 002A56Bladder symptoms assessed with overactive bladder questionnaire in Parkinson's disease
Auteurs : Elisa Iacovelli ; Francesca Gilio ; Giuseppe Meco ; Francesco Fattapposta ; Nicola Vanacore ; Livia Brusa ; Elena Giacomelli ; Maria Gabriele ; Alfonso Rubino ; Nicoletta Locuratolo ; Cesare Iani ; Floriana Pichiorri ; Carlo Colosimo ; Antonio Carbone ; Giovanni Palleschi ; Maurizio InghilleriSource :
- Movement Disorders [ 0885-3185 ] ; 2010-07-15.
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Abstract
In Parkinson's disease (PD) the urinary dysfunction manifests primarily with symptoms of overactive bladder (OAB). The OAB questionnaire (OAB‐q) is a measure designed to assess the impact of OAB symptoms on health‐related quality of life. In this study, we quantified the urinary symptoms in a large cohort of PD patients by using the OAB‐q short form. Possible correlations between the OAB‐q and clinical features were tested. Three hundred and two PD patients were enrolled in the study. Correlations between the OAB‐q and sex, age, Unified Parkinson's Disease Rating Scale part III (UPDRS‐III), Hoehn‐Yahr (H‐Y) staging, disease duration, and treatment were analyzed. Data were compared with a large cohort of 303 age‐matched healthy subjects. The OAB‐q yielded significantly higher scores in PD patients than in healthy subjects. In the group of PD patients, all the variables tested were similar between men and women. Pearson's coefficient showed a significant correlation between mean age, disease duration, mean OAB‐q scores, UPDRS‐III scores, and H‐Y staging. A multiple linear regression analysis showed that OAB‐q values were significantly influenced by age and UPDRS‐III. No statistical correlations were found between OAB‐q scores and drug therapy or the equivalent levodopa dose, whilst the items relating to the nocturia symptoms were significantly associated with the equivalent levodopa dose. Our findings suggest that bladder dysfunction assessed by OAB‐q mainly correlates with UPDRS‐III scores for severity of motor impairment, possibly reflecting the known role of the decline in nigrostriatal dopaminergic function in bladder dysfunction associated with PD and patients' age. Our study also suggests that the OAB‐q is a simple, easily administered test that can objectively evaluate bladder function in patients with PD. © 2010 Movement Disorder Society
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DOI: 10.1002/mds.23093
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Eugenio Hospital, Rome, Italy</mods:affiliation></affiliation></author><author><name sortKey="Giacomelli, Elena" sort="Giacomelli, Elena" uniqKey="Giacomelli E" first="Elena" last="Giacomelli">Elena Giacomelli</name><affiliation><mods:affiliation>Department of Neurological Sciences, University of Rome “Sapienza”, Rome, Italy</mods:affiliation></affiliation></author><author><name sortKey="Gabriele, Maria" sort="Gabriele, Maria" uniqKey="Gabriele M" first="Maria" last="Gabriele">Maria Gabriele</name><affiliation><mods:affiliation>Department of Neurological Sciences, University of Rome “Sapienza”, Rome, Italy</mods:affiliation></affiliation></author><author><name sortKey="Rubino, Alfonso" sort="Rubino, Alfonso" uniqKey="Rubino A" first="Alfonso" last="Rubino">Alfonso Rubino</name><affiliation><mods:affiliation>Department of Neurological Sciences, University of Rome “Sapienza”, Rome, Italy</mods:affiliation></affiliation></author><author><name sortKey="Locuratolo, Nicoletta" sort="Locuratolo, Nicoletta" uniqKey="Locuratolo N" first="Nicoletta" last="Locuratolo">Nicoletta Locuratolo</name><affiliation><mods:affiliation>Department of Neurology and Otolaryngology, University of Rome “Sapienza”, Rome, Italy</mods:affiliation></affiliation></author><author><name sortKey="Iani, Cesare" sort="Iani, Cesare" uniqKey="Iani C" first="Cesare" last="Iani">Cesare Iani</name><affiliation><mods:affiliation>Neurology Unit, S. Eugenio Hospital, Rome, Italy</mods:affiliation></affiliation></author><author><name sortKey="Pichiorri, Floriana" sort="Pichiorri, Floriana" uniqKey="Pichiorri F" first="Floriana" last="Pichiorri">Floriana Pichiorri</name><affiliation><mods:affiliation>Department of Neurological Sciences, University of Rome “Sapienza”, Rome, Italy</mods:affiliation></affiliation></author><author><name sortKey="Colosimo, Carlo" sort="Colosimo, Carlo" uniqKey="Colosimo C" first="Carlo" last="Colosimo">Carlo Colosimo</name><affiliation><mods:affiliation>Department of Neurological Sciences, University of Rome “Sapienza”, Rome, Italy</mods:affiliation></affiliation></author><author><name sortKey="Carbone, Antonio" sort="Carbone, Antonio" uniqKey="Carbone A" first="Antonio" last="Carbone">Antonio Carbone</name><affiliation><mods:affiliation>Department of Urology, A.Fiorini Hospital Polo Pontino, Terracina (LT) University of Rome “Sapienza”, Rome, Italy</mods:affiliation></affiliation></author><author><name sortKey="Palleschi, Giovanni" sort="Palleschi, Giovanni" uniqKey="Palleschi G" first="Giovanni" last="Palleschi">Giovanni Palleschi</name><affiliation><mods:affiliation>Department of Urology, A.Fiorini Hospital Polo Pontino, Terracina (LT) University of Rome “Sapienza”, Rome, Italy</mods:affiliation></affiliation></author><author><name sortKey="Inghilleri, Maurizio" sort="Inghilleri, Maurizio" uniqKey="Inghilleri M" first="Maurizio" last="Inghilleri">Maurizio Inghilleri</name><affiliation><mods:affiliation>Department of Neurological Sciences, University of Rome “Sapienza”, Rome, Italy</mods:affiliation></affiliation><affiliation><mods:affiliation>S. Raffaele Institute IRCCS, University of Rome “Sapienza”, Rome, Italy</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2010-07-15">2010-07-15</date><biblScope unit="volume">25</biblScope><biblScope unit="issue">9</biblScope><biblScope unit="page" from="1203">1203</biblScope><biblScope unit="page" to="1209">1209</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">501E37298910FEDC50B885F2044626020D5EA964</idno><idno type="DOI">10.1002/mds.23093</idno><idno type="ArticleID">MDS23093</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>OABq</term><term>Parkinson's disease</term><term>bladder dysfunctions</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In Parkinson's disease (PD) the urinary dysfunction manifests primarily with symptoms of overactive bladder (OAB). The OAB questionnaire (OAB‐q) is a measure designed to assess the impact of OAB symptoms on health‐related quality of life. In this study, we quantified the urinary symptoms in a large cohort of PD patients by using the OAB‐q short form. Possible correlations between the OAB‐q and clinical features were tested. Three hundred and two PD patients were enrolled in the study. Correlations between the OAB‐q and sex, age, Unified Parkinson's Disease Rating Scale part III (UPDRS‐III), Hoehn‐Yahr (H‐Y) staging, disease duration, and treatment were analyzed. Data were compared with a large cohort of 303 age‐matched healthy subjects. The OAB‐q yielded significantly higher scores in PD patients than in healthy subjects. In the group of PD patients, all the variables tested were similar between men and women. Pearson's coefficient showed a significant correlation between mean age, disease duration, mean OAB‐q scores, UPDRS‐III scores, and H‐Y staging. A multiple linear regression analysis showed that OAB‐q values were significantly influenced by age and UPDRS‐III. No statistical correlations were found between OAB‐q scores and drug therapy or the equivalent levodopa dose, whilst the items relating to the nocturia symptoms were significantly associated with the equivalent levodopa dose. Our findings suggest that bladder dysfunction assessed by OAB‐q mainly correlates with UPDRS‐III scores for severity of motor impairment, possibly reflecting the known role of the decline in nigrostriatal dopaminergic function in bladder dysfunction associated with PD and patients' age. Our study also suggests that the OAB‐q is a simple, easily administered test that can objectively evaluate bladder function in patients with PD. © 2010 Movement Disorder Society</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Elisa Iacovelli MD</name><affiliations><json:string>Department of Neurological Sciences, University of Rome “Sapienza”, Rome, Italy</json:string></affiliations></json:item><json:item><name>Francesca Gilio MD</name><affiliations><json:string>Neurology and Neurophysiopathology Unit, S. Pertini Hospital, Rome, Italy</json:string></affiliations></json:item><json:item><name>Giuseppe Meco MD</name><affiliations><json:string>Department of Neurological Sciences, University of Rome “Sapienza”, Rome, Italy</json:string></affiliations></json:item><json:item><name>Francesco Fattapposta MD</name><affiliations><json:string>Department of Neurology and Otolaryngology, University of Rome “Sapienza”, Rome, Italy</json:string></affiliations></json:item><json:item><name>Nicola Vanacore MD</name><affiliations><json:string>Italian National Institute of Health (ISS), Rome, Italy</json:string></affiliations></json:item><json:item><name>Livia Brusa MD</name><affiliations><json:string>Neurology Unit, S. Eugenio Hospital, Rome, Italy</json:string></affiliations></json:item><json:item><name>Elena Giacomelli MD</name><affiliations><json:string>Department of Neurological Sciences, University of Rome “Sapienza”, Rome, Italy</json:string></affiliations></json:item><json:item><name>Maria Gabriele MD</name><affiliations><json:string>Department of Neurological Sciences, University of Rome “Sapienza”, Rome, Italy</json:string></affiliations></json:item><json:item><name>Alfonso Rubino MD</name><affiliations><json:string>Department of Neurological Sciences, University of Rome “Sapienza”, Rome, Italy</json:string></affiliations></json:item><json:item><name>Nicoletta Locuratolo MD</name><affiliations><json:string>Department of Neurology and Otolaryngology, University of Rome “Sapienza”, Rome, Italy</json:string></affiliations></json:item><json:item><name>Cesare Iani MD</name><affiliations><json:string>Neurology Unit, S. Eugenio Hospital, Rome, Italy</json:string></affiliations></json:item><json:item><name>Floriana Pichiorri MD</name><affiliations><json:string>Department of Neurological Sciences, University of Rome “Sapienza”, Rome, Italy</json:string></affiliations></json:item><json:item><name>Carlo Colosimo MD</name><affiliations><json:string>Department of Neurological Sciences, University of Rome “Sapienza”, Rome, Italy</json:string></affiliations></json:item><json:item><name>Antonio Carbone MD</name><affiliations><json:string>Department of Urology, A.Fiorini Hospital Polo Pontino, Terracina (LT) University of Rome “Sapienza”, Rome, Italy</json:string></affiliations></json:item><json:item><name>Giovanni Palleschi MD</name><affiliations><json:string>Department of Urology, A.Fiorini Hospital Polo Pontino, Terracina (LT) University of Rome “Sapienza”, Rome, Italy</json:string></affiliations></json:item><json:item><name>Maurizio Inghilleri MD, PhD</name><affiliations><json:string>Department of Neurological Sciences, University of Rome “Sapienza”, Rome, Italy</json:string><json:string>S. Raffaele Institute IRCCS, University of Rome “Sapienza”, Rome, Italy</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Parkinson's disease</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>bladder dysfunctions</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>OABq</value></json:item></subject><articleId><json:string>MDS23093</json:string></articleId><language><json:string>eng</json:string></language><abstract>In Parkinson's disease (PD) the urinary dysfunction manifests primarily with symptoms of overactive bladder (OAB). The OAB questionnaire (OAB‐q) is a measure designed to assess the impact of OAB symptoms on health‐related quality of life. In this study, we quantified the urinary symptoms in a large cohort of PD patients by using the OAB‐q short form. Possible correlations between the OAB‐q and clinical features were tested. Three hundred and two PD patients were enrolled in the study. Correlations between the OAB‐q and sex, age, Unified Parkinson's Disease Rating Scale part III (UPDRS‐III), Hoehn‐Yahr (H‐Y) staging, disease duration, and treatment were analyzed. Data were compared with a large cohort of 303 age‐matched healthy subjects. The OAB‐q yielded significantly higher scores in PD patients than in healthy subjects. In the group of PD patients, all the variables tested were similar between men and women. Pearson's coefficient showed a significant correlation between mean age, disease duration, mean OAB‐q scores, UPDRS‐III scores, and H‐Y staging. A multiple linear regression analysis showed that OAB‐q values were significantly influenced by age and UPDRS‐III. No statistical correlations were found between OAB‐q scores and drug therapy or the equivalent levodopa dose, whilst the items relating to the nocturia symptoms were significantly associated with the equivalent levodopa dose. Our findings suggest that bladder dysfunction assessed by OAB‐q mainly correlates with UPDRS‐III scores for severity of motor impairment, possibly reflecting the known role of the decline in nigrostriatal dopaminergic function in bladder dysfunction associated with PD and patients' age. Our study also suggests that the OAB‐q is a simple, easily administered test that can objectively evaluate bladder function in patients with PD. © 2010 Movement Disorder Society</abstract><qualityIndicators><score>7.028</score><pdfVersion>1.3</pdfVersion><pdfPageSize>612 x 810 pts</pdfPageSize><refBibsNative>true</refBibsNative><keywordCount>3</keywordCount><abstractCharCount>1875</abstractCharCount><pdfWordCount>4028</pdfWordCount><pdfCharCount>26750</pdfCharCount><pdfPageCount>7</pdfPageCount><abstractWordCount>277</abstractWordCount></qualityIndicators><title>Bladder symptoms assessed with overactive bladder questionnaire in Parkinson's disease</title><genre><json:string>article</json:string></genre><host><volume>25</volume><publisherId><json:string>MDS</json:string></publisherId><pages><total>7</total><last>1209</last><first>1203</first></pages><issn><json:string>0885-3185</json:string></issn><issue>9</issue><subject><json:item><value>Research Article</value></json:item></subject><genre><json:string>Journal</json:string></genre><language><json:string>unknown</json:string></language><eissn><json:string>1531-8257</json:string></eissn><title>Movement Disorders</title><doi><json:string>10.1002/(ISSN)1531-8257</json:string></doi></host><publicationDate>2010</publicationDate><copyrightDate>2010</copyrightDate><doi><json:string>10.1002/mds.23093</json:string></doi><id>501E37298910FEDC50B885F2044626020D5EA964</id><fulltext><json:item><original>true</original><mimetype>application/pdf</mimetype><extension>pdf</extension><uri>https://api.istex.fr/document/501E37298910FEDC50B885F2044626020D5EA964/fulltext/pdf</uri></json:item><json:item><original>false</original><mimetype>application/zip</mimetype><extension>zip</extension><uri>https://api.istex.fr/document/501E37298910FEDC50B885F2044626020D5EA964/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/501E37298910FEDC50B885F2044626020D5EA964/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Bladder symptoms assessed with overactive bladder questionnaire in Parkinson's disease</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><availability><p>WILEY</p></availability><date>2010</date></publicationStmt><notesStmt><note type="content">*Potential conflict of interest: Nothing to report.</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Bladder symptoms assessed with overactive bladder questionnaire in Parkinson's disease</title><author><persName><forename type="first">Elisa</forename><surname>Iacovelli</surname></persName><roleName type="degree">MD</roleName><affiliation>Department of Neurological Sciences, University of Rome “Sapienza”, Rome, Italy</affiliation></author><author><persName><forename type="first">Francesca</forename><surname>Gilio</surname></persName><roleName type="degree">MD</roleName><affiliation>Neurology and Neurophysiopathology Unit, S. Pertini Hospital, Rome, Italy</affiliation></author><author><persName><forename type="first">Giuseppe</forename><surname>Meco</surname></persName><roleName type="degree">MD</roleName><affiliation>Department of Neurological Sciences, University of Rome “Sapienza”, Rome, Italy</affiliation></author><author><persName><forename type="first">Francesco</forename><surname>Fattapposta</surname></persName><roleName type="degree">MD</roleName><affiliation>Department of Neurology and Otolaryngology, University of Rome “Sapienza”, Rome, Italy</affiliation></author><author><persName><forename type="first">Nicola</forename><surname>Vanacore</surname></persName><roleName type="degree">MD</roleName><affiliation>Italian National Institute of Health (ISS), Rome, Italy</affiliation></author><author><persName><forename type="first">Livia</forename><surname>Brusa</surname></persName><roleName type="degree">MD</roleName><affiliation>Neurology Unit, S. Eugenio Hospital, Rome, Italy</affiliation></author><author><persName><forename type="first">Elena</forename><surname>Giacomelli</surname></persName><roleName type="degree">MD</roleName><affiliation>Department of Neurological Sciences, University of Rome “Sapienza”, Rome, Italy</affiliation></author><author><persName><forename type="first">Maria</forename><surname>Gabriele</surname></persName><roleName type="degree">MD</roleName><affiliation>Department of Neurological Sciences, University of Rome “Sapienza”, Rome, Italy</affiliation></author><author><persName><forename type="first">Alfonso</forename><surname>Rubino</surname></persName><roleName type="degree">MD</roleName><affiliation>Department of Neurological Sciences, University of Rome “Sapienza”, Rome, Italy</affiliation></author><author><persName><forename type="first">Nicoletta</forename><surname>Locuratolo</surname></persName><roleName type="degree">MD</roleName><affiliation>Department of Neurology and Otolaryngology, University of Rome “Sapienza”, Rome, Italy</affiliation></author><author><persName><forename type="first">Cesare</forename><surname>Iani</surname></persName><roleName type="degree">MD</roleName><affiliation>Neurology Unit, S. Eugenio Hospital, Rome, Italy</affiliation></author><author><persName><forename type="first">Floriana</forename><surname>Pichiorri</surname></persName><roleName type="degree">MD</roleName><affiliation>Department of Neurological Sciences, University of Rome “Sapienza”, Rome, Italy</affiliation></author><author><persName><forename type="first">Carlo</forename><surname>Colosimo</surname></persName><roleName type="degree">MD</roleName><affiliation>Department of Neurological Sciences, University of Rome “Sapienza”, Rome, Italy</affiliation></author><author><persName><forename type="first">Antonio</forename><surname>Carbone</surname></persName><roleName type="degree">MD</roleName><affiliation>Department of Urology, A.Fiorini Hospital Polo Pontino, Terracina (LT) University of Rome “Sapienza”, Rome, Italy</affiliation></author><author><persName><forename type="first">Giovanni</forename><surname>Palleschi</surname></persName><roleName type="degree">MD</roleName><affiliation>Department of Urology, A.Fiorini Hospital Polo Pontino, Terracina (LT) University of Rome “Sapienza”, Rome, Italy</affiliation></author><author><persName><forename type="first">Maurizio</forename><surname>Inghilleri</surname></persName><roleName type="degree">MD, PhD</roleName><note type="correspondence"><p>Correspondence: Viale dell'Università 30, 00185 Rome, Italy</p></note><affiliation>Department of Neurological Sciences, University of Rome “Sapienza”, Rome, Italy</affiliation><affiliation>S. Raffaele Institute IRCCS, University of Rome “Sapienza”, Rome, Italy</affiliation></author></analytic><monogr><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="pISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><idno type="DOI">10.1002/(ISSN)1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2010-07-15"></date><biblScope unit="volume">25</biblScope><biblScope unit="issue">9</biblScope><biblScope unit="page" from="1203">1203</biblScope><biblScope unit="page" to="1209">1209</biblScope></imprint></monogr><idno type="istex">501E37298910FEDC50B885F2044626020D5EA964</idno><idno type="DOI">10.1002/mds.23093</idno><idno type="ArticleID">MDS23093</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2010</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>In Parkinson's disease (PD) the urinary dysfunction manifests primarily with symptoms of overactive bladder (OAB). The OAB questionnaire (OAB‐q) is a measure designed to assess the impact of OAB symptoms on health‐related quality of life. In this study, we quantified the urinary symptoms in a large cohort of PD patients by using the OAB‐q short form. Possible correlations between the OAB‐q and clinical features were tested. Three hundred and two PD patients were enrolled in the study. Correlations between the OAB‐q and sex, age, Unified Parkinson's Disease Rating Scale part III (UPDRS‐III), Hoehn‐Yahr (H‐Y) staging, disease duration, and treatment were analyzed. Data were compared with a large cohort of 303 age‐matched healthy subjects. The OAB‐q yielded significantly higher scores in PD patients than in healthy subjects. In the group of PD patients, all the variables tested were similar between men and women. Pearson's coefficient showed a significant correlation between mean age, disease duration, mean OAB‐q scores, UPDRS‐III scores, and H‐Y staging. A multiple linear regression analysis showed that OAB‐q values were significantly influenced by age and UPDRS‐III. No statistical correlations were found between OAB‐q scores and drug therapy or the equivalent levodopa dose, whilst the items relating to the nocturia symptoms were significantly associated with the equivalent levodopa dose. Our findings suggest that bladder dysfunction assessed by OAB‐q mainly correlates with UPDRS‐III scores for severity of motor impairment, possibly reflecting the known role of the decline in nigrostriatal dopaminergic function in bladder dysfunction associated with PD and patients' age. Our study also suggests that the OAB‐q is a simple, easily administered test that can objectively evaluate bladder function in patients with PD. © 2010 Movement Disorder Society</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>Parkinson's disease</term></item><item><term>bladder dysfunctions</term></item><item><term>OABq</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>article category</head><item><term>Research Article</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2009-10-20">Received</change><change when="2010-02-18">Registration</change><change when="2010-07-15">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/501E37298910FEDC50B885F2044626020D5EA964/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Wiley Subscription Services, Inc., A Wiley Company</publisherName><publisherLoc>Hoboken</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1531-8257</doi><issn type="print">0885-3185</issn><issn type="electronic">1531-8257</issn><idGroup><id type="product" value="MDS"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="MOVEMENT DISORDERS">Movement Disorders</title><title type="short">Mov. 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type="tableTotal" number="3"></count><count type="referenceTotal" number="35"></count><count type="wordTotal" number="5209"></count></countGroup><titleGroup><title type="main" xml:lang="en">Bladder symptoms assessed with overactive bladder questionnaire in Parkinson's disease<link href="#fn1"></link></title><title type="short" xml:lang="en">Symptoms Assessed with Overactive Bladder Questionnaire</title></titleGroup><creators><creator xml:id="au1" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Elisa</givenNames><familyName>Iacovelli</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au2" creatorRole="author" affiliationRef="#af2"><personName><givenNames>Francesca</givenNames><familyName>Gilio</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au3" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Giuseppe</givenNames><familyName>Meco</familyName><degrees>MD</degrees></personName></creator><creator 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Correlations between the OAB‐q and sex, age, Unified Parkinson's Disease Rating Scale part III (UPDRS‐III), Hoehn‐Yahr (H‐Y) staging, disease duration, and treatment were analyzed. Data were compared with a large cohort of 303 age‐matched healthy subjects. The OAB‐q yielded significantly higher scores in PD patients than in healthy subjects. In the group of PD patients, all the variables tested were similar between men and women. Pearson's coefficient showed a significant correlation between mean age, disease duration, mean OAB‐q scores, UPDRS‐III scores, and H‐Y staging. A multiple linear regression analysis showed that OAB‐q values were significantly influenced by age and UPDRS‐III. No statistical correlations were found between OAB‐q scores and drug therapy or the equivalent levodopa dose, whilst the items relating to the nocturia symptoms were significantly associated with the equivalent levodopa dose. Our findings suggest that bladder dysfunction assessed by OAB‐q mainly correlates with UPDRS‐III scores for severity of motor impairment, possibly reflecting the known role of the decline in nigrostriatal dopaminergic function in bladder dysfunction associated with PD and patients' age. Our study also suggests that the OAB‐q is a simple, easily administered test that can objectively evaluate bladder function in patients with PD. © 2010 Movement Disorder Society</p></abstract></abstractGroup></contentMeta><noteGroup><note xml:id="fn1"><p>Potential conflict of interest: Nothing to report.</p></note></noteGroup></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Bladder symptoms assessed with overactive bladder questionnaire in Parkinson's disease</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Symptoms Assessed with Overactive Bladder Questionnaire</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Bladder symptoms assessed with overactive bladder questionnaire in Parkinson's disease</title></titleInfo><name type="personal"><namePart type="given">Elisa</namePart><namePart type="family">Iacovelli</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurological Sciences, University of Rome “Sapienza”, Rome, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Francesca</namePart><namePart type="family">Gilio</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Neurology and Neurophysiopathology Unit, S. Pertini Hospital, Rome, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Giuseppe</namePart><namePart type="family">Meco</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurological Sciences, University of Rome “Sapienza”, Rome, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Francesco</namePart><namePart type="family">Fattapposta</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology and Otolaryngology, University of Rome “Sapienza”, Rome, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Nicola</namePart><namePart type="family">Vanacore</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Italian National Institute of Health (ISS), Rome, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Livia</namePart><namePart type="family">Brusa</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Neurology Unit, S. 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Eugenio Hospital, Rome, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Floriana</namePart><namePart type="family">Pichiorri</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurological Sciences, University of Rome “Sapienza”, Rome, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Carlo</namePart><namePart type="family">Colosimo</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurological Sciences, University of Rome “Sapienza”, Rome, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Antonio</namePart><namePart type="family">Carbone</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Urology, A.Fiorini Hospital Polo Pontino, Terracina (LT) University of Rome “Sapienza”, Rome, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Giovanni</namePart><namePart type="family">Palleschi</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Urology, A.Fiorini Hospital Polo Pontino, Terracina (LT) University of Rome “Sapienza”, Rome, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Maurizio</namePart><namePart type="family">Inghilleri</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Department of Neurological Sciences, University of Rome “Sapienza”, Rome, Italy</affiliation><affiliation>S. Raffaele Institute IRCCS, University of Rome “Sapienza”, Rome, Italy</affiliation><description>Correspondence: Viale dell'Università 30, 00185 Rome, Italy</description><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2010-07-15</dateIssued><dateCaptured encoding="w3cdtf">2009-10-20</dateCaptured><dateValid encoding="w3cdtf">2010-02-18</dateValid><copyrightDate encoding="w3cdtf">2010</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="tables">3</extent><extent unit="references">35</extent><extent unit="words">5209</extent></physicalDescription><abstract lang="en">In Parkinson's disease (PD) the urinary dysfunction manifests primarily with symptoms of overactive bladder (OAB). The OAB questionnaire (OAB‐q) is a measure designed to assess the impact of OAB symptoms on health‐related quality of life. In this study, we quantified the urinary symptoms in a large cohort of PD patients by using the OAB‐q short form. Possible correlations between the OAB‐q and clinical features were tested. Three hundred and two PD patients were enrolled in the study. Correlations between the OAB‐q and sex, age, Unified Parkinson's Disease Rating Scale part III (UPDRS‐III), Hoehn‐Yahr (H‐Y) staging, disease duration, and treatment were analyzed. Data were compared with a large cohort of 303 age‐matched healthy subjects. The OAB‐q yielded significantly higher scores in PD patients than in healthy subjects. In the group of PD patients, all the variables tested were similar between men and women. Pearson's coefficient showed a significant correlation between mean age, disease duration, mean OAB‐q scores, UPDRS‐III scores, and H‐Y staging. A multiple linear regression analysis showed that OAB‐q values were significantly influenced by age and UPDRS‐III. No statistical correlations were found between OAB‐q scores and drug therapy or the equivalent levodopa dose, whilst the items relating to the nocturia symptoms were significantly associated with the equivalent levodopa dose. Our findings suggest that bladder dysfunction assessed by OAB‐q mainly correlates with UPDRS‐III scores for severity of motor impairment, possibly reflecting the known role of the decline in nigrostriatal dopaminergic function in bladder dysfunction associated with PD and patients' age. Our study also suggests that the OAB‐q is a simple, easily administered test that can objectively evaluate bladder function in patients with PD. © 2010 Movement Disorder Society</abstract><note type="content">*Potential conflict of interest: Nothing to report.</note><subject lang="en"><genre>Keywords</genre><topic>Parkinson's disease</topic><topic>bladder dysfunctions</topic><topic>OABq</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title></titleInfo><titleInfo type="abbreviated"><title>Mov. Disord.</title></titleInfo><genre type="Journal">journal</genre><subject><genre>article category</genre><topic>Research Article</topic></subject><identifier type="ISSN">0885-3185</identifier><identifier type="eISSN">1531-8257</identifier><identifier type="DOI">10.1002/(ISSN)1531-8257</identifier><identifier type="PublisherID">MDS</identifier><part><date>2010</date><detail type="volume"><caption>vol.</caption><number>25</number></detail><detail type="issue"><caption>no.</caption><number>9</number></detail><extent unit="pages"><start>1203</start><end>1209</end><total>7</total></extent></part></relatedItem><identifier type="istex">501E37298910FEDC50B885F2044626020D5EA964</identifier><identifier type="DOI">10.1002/mds.23093</identifier><identifier type="ArticleID">MDS23093</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2010 Movement Disorder Society</accessCondition><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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